Efek Latihan Aerobik Terhadap Irisin Dalam Mencegah Obesitas

Naufal Firdaus(1*), Sugiharto Sugiharto(2), Desiana Merawati(3),

(1) Universitas Negeri Malang
(2) Universitas Negeri Malang
(3) Universitas Negeri Malang
(*) Corresponding Author



Abstract


Aerobic exercise is rated as the most effective strategy for treating obesity. Aerobic exercise induces irisin to stimulate tissue browning. The important role of irisin in the regulation of metabolism and reduction of body fat is that it can increase energy expenditure. The method of this article is to look at several journal articles that compare one journal to another. In practice, the results of the analysis of research journals are combined based on their respective similarities and differences to produce new conclusions. The results Aerobic exercise induces the release of irisin via peroxisome proliferation activated receptor-γ (PPAR-γ) and PGC-1α. Exercise that is performed at intervals increases PGC-1α activation, especially in the heart and skeletal muscles and improves various metabolic parameters such as insulin sensitivity and signaling, promotes AMPK activation, PGC1α phosphorylation and FNDC5 production, followed by cleavage of FNDC5 to produce irisin which will be released into the blood circulation. . The release of irisin into the blood circulation activates the AMPK pathway by reducing intracellular ATP or by increasing the intracellular calcium concentration in muscle cells, causing increased glucose and lipid uptake and increased fat metabolism. Aerobic exercise can increase irisin in an obese person which has an effect on energy expenditure so that fat in the body is reduced and subsequently results in weight loss.


Keywords


Latihan aerobik; irisin; obesitas

Full Text:

PDF

References


Aghjayan, S. L., Lesnovskaya, A., Esteban‐Cornejo, I., Peven, J. C., Stillman, C. M., & Erickson, K. I. (2021). Aerobic exercise, cardiorespiratory fitness, and the human hippocampus. Hippocampus, 31(8), 817-844. https://doi.org/10.1002/hipo.23337

Américo, ALV, Muller, CR, Vecchiatto, B., Martucci, LF, Fonseca-Alaniz, MH, & Evangelista, FS (2019). Pelatihan latihan aerobik mencegah obesitas dan resistensi insulin terlepas dari modulasi sistem renin angiotensin di jaringan adiposa putih subkutan. PloS satu , 14 (4), e0215896. https://doi.org/10.1371/journal.pone.0215896

Andrade, P. A., Silveira, B. S., Rodrigues, A. C., da Silva, F. O., Rosa, C. B., & Alfenas, R. G. (2018). Effect of exercise on concentrations of irisin in overweight individuals: a systematic review. Science & Sports, 33(2), 80-89. https://doi.org/10.1016/j.scispo.2017.11.002

Arhire, L. I., Mihalache, L., & Covasa, M. (2019). Irisin: a hope in understanding and managing obesity and metabolic syndrome. Frontiers in endocrinology, 10, 524. https://doi.org/10.3389/fendo.2019.00524

Cullen, T., Clarke, N. D., Hill, M., Menzies, C., Pugh, C. J., Steward, C. J., & Thake, C. D. (2020). The health benefits of passive heating and aerobic exercise: To what extent do the mechanisms overlap?. Journal of Applied Physiology, 129(6), 1304-1309. https://doi.org/10.1152/japplphysiol.00608.2020

Elizondo-Montemayor, L., Mendoza-Lara, G., Gutierrez-DelBosque, G.,Peschard-Franco, M., Nieblas, B., & Garcia-Rivas, G. (2018). Relationship of circulating irisin with body composition, physical activity, and cardiovascular and metabolic disorders in the pediatric population. International Journal of Molecular Sciences, 19(12), 3727.https://doi.org/10.3390/ijms19123727

Fu, T., Li, C., Sun, Z., Yan, B., Wu, Y., Huang, Z., & Yin, X. (2022). Integrin αV Mediates the Effects of Irisin on Human Mature Adipocytes. Obesity Facts, 15(3), 442-450. https://doi.org/10.1159/000523871

Gizaw, M., Anandakumar, P., & Debela, T. (2017). A review on the role of irisin in insulin resistance and type 2 diabetes mellitus. Journal of pharmacopuncture, 20(4), 235. https://doi.org/10.3831%2FKPI.2017.20.029

Jandova, T., Buendía-Romero, A., Polanska, H., Hola, V., Rihova, M., Vetrovsky, T., ... & Steffl, M. (2021, October). Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis. In Healthcare (Vol. 9, No. 11, p. 1438). MDPI. https://doi.org/10.3390/healthcare9111438

Korta, P., Pocheć, E., & Mazur-Biały, A. (2019). Irisin as a multifunctional protein: implications for health and certain diseases. Medicina, 55(8), 485. https://doi.org/10.3390/medicina55080485

Marrano, N., Biondi, G., Borrelli, A., Cignarelli, A., Perrini, S., Laviola, L., ... & Natalicchio, A. (2021). Irisin and incretin hormones: Similarities, differences, and implications in type 2 diabetes and obesity. Biomolecules, 11(2), 286. https://doi.org/10.3390/biom11020286

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., ... & Fernández-Real, J. M. (2013). Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 98(4), E769-E778. https://doi.org/10.1210/jc.2012-2749

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., ... & Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS journal, 281(3), 739-749. https://doi.org/10.1111/febs.12619

Parada-Sánchez, S. G., Macias-Cervantes, M. H., PÉREZ-VÁZQUEZ, V., & VARGAS-ORTIZ, K. (2022). The Effects of Different Types of Exercise on Circulating Irisin Levels in Healthy Individuals and in People With Overweight, Metabolic Syndrome and Type 2 Diabetes. Physiological Research, 71(4).

Patel, H., Alkhawam, H., Madanieh, R., Shah, N., Kosmas, C. E., & Vittorio, T. J. (2017). Aerobic vs anaerobic exercise training effects on the cardiovascular system. World journal of cardiology, 9(2), 134. 10.4330/wjc.v9.i2.134

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nature reviews endocrinology, 13(6), 324-337. https://doi.org/10.1038/nrendo.2016.221

Pesce, M., La Fratta, I., Paolucci, T., Grilli, A., Patruno, A., Agostini, F., ... & De Sire, A. (2021). From exercise to cognitive performance: Role of irisin. Applied Sciences, 11(15), 7120. https://doi.org/10.3390/app11157120

Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018). Irisin in metabolic diseases. Endocrine, 59(2), 260-274. https://doi.org/10.1007/s12020-017-1476-1

Rabiee, F., Lachinani, L., Ghaedi, S., Nasr-Esfahani, M. H., Megraw, T. L., & Ghaedi, K. (2020). New insights into the cellular activities of Fndc5/Irisin and its signaling pathways. Cell & Bioscience, 10(1), 1-10.https://DOI:10.1186/s13578-020-00413-3

Rashid, F. A., Abbas, H. J., Naser, N. A., & Ali, A. (2020). Effect of long-term moderate physical exercise on irisin between normal weight and obese men. The Scientific World Journal, 2020.https://doi.org/10.1155/2020/1897027

Said, M. A., Abdelmoneem, M., Almaqhawi, A., Kotob, A. A. H., Alibrahim, M. C., & Bougmiza, I. (2018). Multidisciplinary approach to obesity: Aerobic or resistance physical exercise?. Journal of Exercise Science & Fitness, 16(3), 118-123.https://doi.org/10.1016/j.jesf.2018.11.001

Shabani, R., & Izaddoust, F. (2018). Effects of aerobic training, resistance training, or both on circulating irisin and myostatin in untrained women. Acta Gymnica, 48(2), 47-55.

Teimourian, M., Fatolahi, H., & Mateenhomaei, H. (2020). Effect of different exercise mode and ursolic acid supplementation on FNDC5 and UCP1 gene expression and plasma irisin in rats. Int J Sports Exerc Med, 6(1), 160


Article Metrics

Abstract view : 141 times | PDF view : 23 times

Refbacks

  • There are currently no refbacks.


 



                                                                                                                                              

This is a website that publishes an open-access article distributed under Licensed Creative Commons License Creative Commons License the terms of the Creative Commons Attribution 4.0 International License.