Uji Fitokimia, Sitotoksik, dan Antikanker Ekstrak Makroalga Caulerpa Racemosa (Forsskal) J.Agardh. Terhadap Sel Hela

Muharram Muharram(1), Iwan Dini(2*), Nita Magfirah Ilyas(3),

(1) Universitas Negeri Makassar
(2) Universitas Negeri Makassar
(3) Universitas Negeri Makassar
(*) Corresponding Author




DOI: https://doi.org/10.26858/ijfs.v9i2.54390

Abstract


Abstrak. Penelitian ini bertujuan untuk menguji kandungan fitokimia dan sifat sitotoksik potensi antikanker dari berbagai ekstrak C. racemosa (Forsskal) J. Agardh. Metode yang digunakan meliputi; ekstrak C. racemosa (Forsskal) J. Agardh. diperoleh dengan cara maserasi dengan pelarut organik (n-heksana, etil asetat, aseton, dan etanol). Aktivitas sitotoksik dievaluasi dengan metode BSLT, dan selanjutnya terhadap sel kanker, yaitu sel Hela. Hasil penelitian menunjukkan bahwa Ekstrak n-heksana, etil asetat, aseton, dan etanol makroalga C. racemosa (Forsskal) J. Agardh toksik terhadap Artemia salina Leach. dengan kategori ekstrak heksan sangat toksik dan lanya kategori toksik dengan nilai LC50 berturut-turut 31,62; 46,77; 69,18; dan 389,05 mg/mL. Aktivitas terhadap sel kanker uji yaitu sel kanker Hela, ekstrak etil asetat dan aseton tergolong aktif dengan IC50 19,97 dan 19,60 mg/mL. Hasil penelitian menunjukkan potensi ekstrak untuk dikembangkan menjadi salah satu sumber fitofarmaka antikanker.


Keywords


Caulerpa; antikanker; sitotoksik

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