Cytotoxicity Test of Methanol Extract of Belajang Susu (Scindapsus pictus Hassk.) Against MCF-7 Breast Cancer Cells

Pince Salempa(1*), Muharram Muharram(2), Oslan Jumadi(3), Diana Eka Pratiwi(4), Musniati Azis(5), Nurul Amaliah(6),

(1) University Negeri Makassar
(2) University Negeri Makassar
(3) University Negeri Makassar
(4) University Negeri Makassar
(5) University Negeri Makassar
(6) University Negeri Makassar
(*) Corresponding Author




DOI: https://doi.org/10.26858/ijfs.v8i1.33165

Abstract


Abstract. Belajang Susu Plant (Scindapsus pictus Hassk.) is a species of the genus Scindapsus including the Araceae family which has been traditionally used by the Mambi people for medicine. Plants from the genus Scindapsus contain active compounds such as calcium oxalate, flavonoids sulfate and a mixture of flavones and flavonols sulfate which can be used as anti-inflammatory, analgesic, antioxidant, anticancer and anti-tumor. This study aims to determine the potential of methanol extract of Scindapsus pictus Hassk. as an anticancer. Extraction was carried out by maceration with methanol and then tested for cytotoxicity against MCF-7 cancer cells. The results showed that the methanol extract of Scindapsus pictus Hassk. was very active against MCF-7 breast cancer cells with an IC50 value of 3.9861 μg / mL.

 

Keywords: Belajang susu,  Scindapsus pictus Hassk., MCF-7The first section in your paper


Keywords


Belajang susu, Scindapsus pictus Hassk., MCF-7The first section in your paper

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References


Hutapea, J. R. (2000). Inventaris Tanaman Obat Indonesia (I). Jakarta: Badan Penelitian dan Pengembangan Kesehatan, Departemen Kesehatan RI.

Jumadi, O., Pince S., Ramly and Raoda. (2012). Riset Khusus Eksplorasi Pengetahuan Lokal Etnomodisin & Tumbuhan Obat di Indonesia Berbasis Komunitas. Kerjasama Antara Badan Penelitian & Pengembangan Kesehatan Kementrian Kesehatan RI dengan Lembaga Penelitian Universitas Negeri Makassar.

Kaur, Kuljeet and Rajiv, G. (2016). Ethnobotanical and phytopharmacological review of Scindapsus officinalis (“Gajapippali”). Asian Pacific Journal of Tropical Biomedicine.

Machana S, Weerapreeyakul N, Barusrux S, Nonpunya A, Sripanidkulchai B, Thitimetharoch T. (2011). Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line. Chinese Medical Journal. 6(39): 1-8.

Meiyanto, E. (2008). Ekstrak etanol Biji Buah Pinang (Areca catchu L.) mampu menghambat polferasi dan memacu apoptosis sel MCF-7. Jurnal Farmasi Indonesia, 19 (1), 12 – 19, 2008.

Meyer, B.N., Ferigni, N.R., Putnam, J.E., Jaconsen, L.B., Nichols, D.F., and Mclaughlin, J.L. (1982). Brine Shimp A Con¬venient General Bioassay for Active Plant Constituents. Planta Medica.;45:31- 34.

Pan, L., Chai, H.-B. &Kinghorn, A.D., (2012). Discovery of New Anticancer Agents from Higher Plants. Frontiers in Boscience (Scholar edition), 4, pp.142–156.

Ruddon RR. (2012). What Makes a Cancer Cell a Cancer Cell? Holland-Frei Cancer medicine – edited by Kufe, DW. RE. Pollock, RR. Weichselbaum, et al (edisi ke-6). Hamilton on BC Decker Inc.

Sarkar S, Horn G, Moulton K, Oza A, Byler S, Kokolus S, et al. (2013). Cancer development, progression, and therapy: An epigenetic overview. International Journal of Molecular Sciences. 14(10):21087–113.

Schneider KA. (2011). Counseling about cancer: Strategies for genetic counseling. 3rd ed. New Jersey: Wiley-Blackwell.

Weerapreeyakul N, Nonpunya A, Barustux S, Thitimetharoch T, Sripanidkulchai B. (2012). Evaluation of the anticancer potential of six herbs against a hepatoma cell line. Chinese Medical Journal. 7(15): 1-7.

Weinberg RA. (2007). The Biology of Cancer. New York: Garland Science.

WHO. (2010). Global status report on noncommunicable diseases. Publications of the World Health Organization are available on the WHO web site (www.who.int).

Yuzammi and Reza, R. R. (2015). Scindapsus splendidus Alderw.: ‘Living Type’ yang Tersisa Koleksi Kebun Raya Bogor. Warta Kebun Raya. Vol. 13. No. 2.


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