THE ANALYSIS of TOTAL CHOLESTEROL LEVELS IN MICE (Mus musculus) MALES WHO WERE GIVEN EXTRACTS of METHANOL LEAF CEMBA (Acacia pennata)

Abstract

This study was conducted to determine the activity of the leaf extract Cemba (Acacia pennata) antihyperkolesterolemia against total cholesterol levels in mice (Mus musculus) male ICR strain. Cemba leaves extracted by using 96% methanol by maceration. This study is a completely randomized design (CRD) that consist of five treatments and five repetition i.e normal group, hiperkolesterol group, the group of the giving of the EDC(Ap) with doses of 100, 250, 500 mg/Kg. The extract was dissolved using Carboxy Methyl Cellulose (CMC) 0.5% and given orally in mice which had previously been given a high cholesterol feed. Data were analyzed using Analysis of Variance (ANOVA) using SPSS Program is 2.0 and followed by Tuckey test (α 0.05). The results showed the methanol extract of leaves cemba with the dose of 500 mg / kg hads the highest effectiveness in lowering total cholesterol levels in mice which have hypercholesterolemia with a 47.88% percentage drop. These results are significantly different from hypercholesterolemia group with -7.20 percentage. The granting of leaves extracts cemba (Acacia pennata) are able to decrease the total cholesterol levels of mice (Mus musculus) male hipercholesterolemia.

Keywords: Anti-hypercholesterolemia, Total Blood Cholesterol, Methanol Extract of Cemba Leaf, Male Mice (Mus musculus) ICR strain.