Irisan Profile of Obese Women After Moderate Intensity Aerobic Exercise

Naufal Firdaus(1), Sugiharto Sugiharto(2*), Desiana Merawati(3),

(1) State University of Malang
(2) State University of Malang
(3) State University of Malang
(*) Corresponding Author




DOI: https://doi.org/10.26858/cjpko.v15i2.47729

Abstract


Irisin in obesity was found to be lower than in individuals with normal weight. Low irisin levels lead to decreased metabolism. Low metabolism causes a decrease in muscle mass, storage of triglyceride energy, and accumulation of excess fatty acids in the body which can lead to the risk of obesity. This study aims to prove the effect of moderate-intensity aerobic exercise on increasing irisin levels in obese women. This research method is true experimental with a random calculation design between pretest-posttest groups. A total of 18 obese women aged 20-25 years were actively involved in research activities and were divided into two groups, namely KK (n = 9; control group), and KE (n = 9; experimental group). Aerobic exercise was given using a set intensity of 60-70% HRmax with a treadmill for 45 minutes, 3x/week for 8 weeks. Irisin levels were evaluated before and after the intervention using the ELISA Kit method. The data analysis technique used the Paired Sample T-Test with a 5% confidence level. The results showed the average irisin level between before and after the intervention in KK (0.83±0.97 vs. 0.86±1.25 ng/mL, p=0.961), KE (0.69±0.64 vs. 2.77±1.26 ng/mL, p=0.003). Based on the results of the study it was concluded that aerobic exercise with a set intensity of 60-70% HRmax performed 3x/week for 8 weeks can increase irisin levels in obese women.


Keywords


Irisin; Obesity; Aerobic Exercise.

Full Text:

PDF

References


Archundia-Herrera, C., Macias-Cervantes, M., Ruiz-Muñoz, B., Vargas-Ortiz, K., Kornhauser, C., & Perez-Vazquez, V. (2017). Muscle irisin response to aerobic vs HIIT in overweight female adolescents. Diabetology & metabolic syndrome, 9(1), 1-7. https://doi.org/10.1186/s13098-017-0302-5.

Arhire, L. I., Mihalache, L., & Covasa, M. (2019). Irisin: a hope in understanding and managing obesity and metabolic syndrome. Frontiers in endocrinology, 10, 524. https://doi.org/10.3389/fendo.2019.00524

Arhire, L. I., Mihalache, L., & Covasa, M. (2019). Irisin: a hope in understanding and managing obesity and metabolic syndrome. Frontiers in endocrinology, 10, 524. https://doi.org/10.3389/fendo.2019.00524.

Besse-Patin, A., Montastier, E., Vinel, C., Castan-Laurell, I., Louche, K., Dray, C., ... & Viguerie, N. (2014). Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. International journal of obesity, 38(5), 707-713. https://doi.org/10.1038/ijo.2013.158.

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., ... & Spiegelman, B. M. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468. https://doi.org/10.1038/nature10777.

Daskalopoulou, S. S., Cooke, A. B., Gomez, Y. H., Mutter, A. F., Filippaios, A., Mesfum, E. T., & Mantzoros, C. S. (2014). Plasma irisin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. European journal of endocrinology, 171(3), 343-352. https://doi.org/10.1530/EJE-14-0204.

Efe, T. H., Açar, B., Ertem, A. G., Yayla, K. G., Algül, E., Yayla, Ç., ... & Yeter, E. (2017). Serum irisin level can predict the severity of coronary artery disease in patients with stable angina. Korean circulation journal, 47(1), 44-49. https://doi.org/10.4070/kcj.2016.0079.

Elizondo-Montemayor, L., Mendoza-Lara, G., Gutierrez-DelBosque, G., Peschard-Franco, M., Nieblas, B., & Garcia-Rivas, G. (2018). Relationship of circulating irisin with body composition, physical activity, and cardiovascular and metabolic disorders in the pediatric population. International Journal of Molecular Sciences, 19(12), 3727. https://doi.org/10.3390/ijms19123727.

Fatouros, I. G. (2018). Is irisin the new player in exercise-induced adaptations or not? A 2017 update. Clinical Chemistry and Laboratory Medicine (CCLM), 56(4), 525-548. https://doi.org/10.1515/cclm-2017-0674.

Fukushima, Y., Kurose, S., Shinno, H., Thu, H. C. T., Takao, N., Tsutsumi, H., ... & Kimura, Y. (2016). Effects of body weight reduction on serum irisin and metabolic parameters in obese subjects. Diabetes & metabolism journal, 40(5), 386-395. https://doi.org/10.4093/dmj.2016.40.5.386.

Gaudio, A., Rapisarda, R., Xourafa, A., Zanoli, L., Manfrè, V., Catalano, A., ... & Castellino, P. (2021). Effects of competitive physical activity on serum irisin levels and bone turnover markers. Journal of Endocrinological Investigation, 44(10), 2235-2241. https://doi.org/10.1007/s40618-021-01529-0.

Gizaw, M., Anandakumar, P., & Debela, T. (2017). A review on the role of irisin in insulin resistance and type 2 diabetes mellitus. Journal of pharmacopuncture, 20(4), 235. https://doi.org/10.3831%2FKPI.2017.20.029.

Glück, M., Glück, J., Wiewióra, M., Rogala, B., & Piecuch, J. (2019). Serum irisin, adropin, and preptin in obese patients 6 months after bariatric surgery. Obesity Surgery, 29(10), 3334-3341. https://doi.org/10.1007/s11695-019-03998-y.

Gouda, W., Mageed, L., Shaker, Y., Hamimy, W. I., & Afify, M. (2018). Assessment of Serum Vitamin D and Irisin Levels in Obese Patients. Clinical Laboratory, 64(11). https://doi.org/10.7754/clin.lab.2018.180416.

Hecksteden, A., Wegmann, M., Steffen, A., Kraushaar, J., Morsch, A., Ruppenthal, S., ... & Meyer, T. (2013). Irisin and exercise training in humans–results from a randomized controlled training trial. BMC medicine, 11(1), 1-8. https://doi.org/10.1186/1741-7015-11-235.

Houti, L., Hamani-Medjaoui, I., Lardjam-Hetraf, S. A., Ouhaibi-Djellouli, H., Chougrani, S., Goumidi, L., & Mediene-Benchekor, S. (2016). Prevalence of metabolic syndrome and its related risk factors in the city of Oran, Algeria: the ISOR Study. Ethnicity & disease, 26(1), 99. https://doi.org/10.18865%2Fed.26.1.99.

Huh, J. Y., Panagiotou, G., Mougios, V., Brinkoetter, M., Vamvini, M. T., Schneider, B. E., & Mantzoros, C. S. (2012). FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Metabolism, 61(12), 1725-1738. https://doi.org/10.1016/j.metabol.2012.09.002.

Jandova, T., Buendía-Romero, A., Polanska, H., Hola, V., Rihova, M., Vetrovsky, T., ... & Steffl, M. (2021, October). Long-Term Effect of Exercise on Irisin Blood Levels—Systematic Review and Meta-Analysis. In Healthcare (Vol. 9, No. 11, p. 1438). MDPI. https://doi.org/10.3390/healthcare9111438.

Kim, H. J., Lee, H. J., So, B., Son, J. S., Yoon, D., & Song, W. (2016). Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study. Physiological research, 65(2), 271.

Kim, H. J., Lee, H. J., So, B., Son, J. S., Yoon, D., & Song, W. (2016). Effect of aerobic training and resistance training on circulating irisin level and their association with change of body composition in overweight/obese adults: a pilot study. Physiological research, 65(2), 271.

Lehnig, A. C., & Stanford, K. I. (2018). Exercise-induced adaptations to white and brown adipose tissue. Journal of Experimental Biology, 221(Suppl_1), jeb161570. https://doi.org/10.1242/jeb.161570.

Li, J., Xie, S., Guo, L., Jiang, J., & Chen, H. (2020). Irisin: linking metabolism with heart failure. American Journal of Translational Research, 12(10), 6003.

Liu, J., Cui, X. Y., Yang, Y. Q., Gao, W., Sun, L., Dong, Y. C., & Kou, X. J. (2015). Effects of high-intensity treadmill training on timeliness and plasticity expression of irisin in mice. Eur Rev Med Pharmacol Sci, 19(12), 2168-2173.

Maalouf, G. E., & El Khoury, D. (2019). Exercise-induced irisin, the fat browning myokine, as a potential anticancer agent. Journal of obesity, 2019. https://doi.org/10.1155/2019/6561726.

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., ... & Fernández-Real, J. M. (2013). Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 98(4), E769-E778. https://doi.org/10.1210/jc.2012-2749.

Moreno-Navarrete, J. M., Ortega, F., Serrano, M., Guerra, E., Pardo, G., Tinahones, F., ... & Fernández-Real, J. M. (2013). Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance. The Journal of Clinical Endocrinology & Metabolism, 98(4), E769-E778. https://doi.org/10.1210/jc.2012-2749.

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., ... & Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS journal, 281(3), 739-749. https://doi.org/10.1111/febs.12619.

Pang, M., Yang, J., Rao, J., Wang, H., Zhang, J., Wang, S., ... & Dong, X. (2018). Time-dependent changes in increased levels of plasma irisin and muscle PGC-1α and FNDC5 after exercise in mice. The Tohoku journal of experimental medicine, 244(2), 93-103. https://doi.org/10.1620/tjem.244.93.

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nature reviews endocrinology, 13(6), 324-337. https://doi.org/10.1038/nrendo.2016.221.

Perakakis, N., Triantafyllou, G. A., Fernández-Real, J. M., Huh, J. Y., Park, K. H., Seufert, J., & Mantzoros, C. S. (2017). Physiology and role of irisin in glucose homeostasis. Nature reviews endocrinology, 13(6), 324-337. https://doi.org/10.1038/nrendo.2016.221.

Polyzos, S. A., Anastasilakis, A. D., Efstathiadou, Z. A., Makras, P., Perakakis, N., Kountouras, J., & Mantzoros, C. S. (2018). Irisin in metabolic diseases. Endocrine, 59(2), 260-274. https://doi.org/10.1007/s12020-017-1476-1.

Pranoto, A., Cahyono, M. B. A., Yakobus, R., Izzatunnisa, N., Ramadhan, R. N., Rejeki, P. S., Miftahussurur, M., Effendi, W. I., Wungu, C. D. K., & Yamaoka, Y. (2023). Long-Term Resistance-Endurance Combined Training Reduces Pro-Inflammatory Cytokines in Young Adult Females with Obesity. Sports (Basel, Switzerland), 11(3), 54. https://doi.org/10.3390/sports11030054.

Sahin-Efe, A., Upadhyay, J., Ko, B. J., Dincer, F., Park, K. H., Migdal, A., ... & Mantzoros, C. (2018). Irisin and leptin concentrations in relation to obesity, and developing type 2 diabetes: a cross sectional and a prospective case-control study nested in the Normative Aging Study. Metabolism, 79, 24-32.

Sugiharto, S., Merawati, D., Susanto, H., Pranoto, A., & Taufiq, A. (2022). The exercise-instrumental music program and irisin levels in younger non-professional athletes. Comparative Exercise Physiology, 18(1), 65-73. https://doi.org/10.3920/CEP210015.

Teimourian, M., Fatolahi, H., & Mateenhomaei, H. (2020). Effect of different exercise mode and ursolic acid supplementation on FNDC5 and UCP1 gene expression and plasma irisin in rats. Int J Sports Exerc Med, 6(1), 160.

Ulualan, G., KÜSKÜ KİRAZ, Z. E. Y. N. E. P., & KIREL, B. (2022). Relation of serum irisin levels to obesity and non-alcoholic fatty liver disease. Turkish Journal of Pediatrics, 64(2)

Zhao, M., Zhou, X., Yuan, C., Li, R., Ma, Y., & Tang, X. (2020). Association between serum irisin concentrations and sarcopenia in patients with liver cirrhosis: A cross-sectional study. Scientific Reports, 10(1), 1-9. https://doi.org/10.3389/fphys.2021.620608.


Article Metrics

Abstract view : 121 times | PDF view : 16 times

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 Naufal Firdaus, Sugiharto Sugiharto, Desiana Merawati

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

COMPETITOR IS LICENSED BY :

 Creative Commons License COMPETITOR is licensed under a Creative Commons Attribution 4.0 International License.


COMPETITOR EDITORIAL LOCATION :

width= Kampus FIK Banta Bantaeng, Jalan Wijaya Kusuma Nomor 14, Rappocini, Makassar, Postal Code 90222


COMPETITOR IS INDEXED BY