Latihan Fisik & Sekresi PGC-1α Pada Obesitas

Arya Dwi Prastickho(1*), Desiana Merawati(2), Sugiharto Sugiharto(3),

(1) Universitas Negeri Malang
(2) Universitas Negeri Malang
(3) Universitas Negeri Malang
(*) Corresponding Author


Peroxisome proliferator activates gamma coactivator 1α (PGC-1α) receptors associated with oxidizing activity in adipose tissue and muscle, which is the prevention of increased obesity through non-pharmacological therapy. Physical exercise is believed to be a trigger for PGC-1α secretion as a strategy to prevent an increase in the prevalence of obesity and prevent the occurrence of metabolic syndrome. Physical exercise also improves metabolic health in obese individuals. Physical exercise is also believed to increase PGC-1α levels in obese individuals. after exercise, the thermogenic gene is expected to remain active. These conditions are favorable and attractive for the browning process to maintain homeostasis in response to a decrease in the AMP/ATP ratio and increased biogenesis in mitochondria. The decrease in AMP/ATP led to active AMPK, the ratio observed 3 hours after exercise. AMPK activation triggers activation of the PGC-1α gene receptor stimulating an increase in FNDC-5, which then cleaves into circulating irisin to activate UCP-1. Consequently, PGC-1α-induced UCP-1 activation enhances browning. The method of this article is to look at several journal articles and compare one journal with another, in the sense that the results of the analysis of research journals are combined based on their similarities and differences to draw new conclusions. According to previous studies, it was also shown that moderate and high-intensity exercise was proven to increase PGC-1α levels in obese individuals, both acutely and chronically.


Latihan Fisik; Metabolisme; PGC-1α; Obesitas

Full Text:



Bell, C. G., Walley, A. J., & Froguel, P. (2005). The genetics of human obesity. Nature reviews genetics, 6(3), 221-234.

Boström, P., Wu, J., Jedrychowski, M. P., Korde, A., Ye, L., Lo, J. C., ... & Spiegelman, B. M. (2012). A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature, 481(7382), 463-468.

Castro, E. A., Carraça, E. V., Cupeiro, R., López-Plaza, B., Teixeira, P. J., González-Lamuño, D., & Peinado, A. B. (2020). The effects of the type of exercise and physical activity on eating behavior and body composition in overweight and obese subjects. Nutrients, 12(2), 557.

Chooi, Y. C., Ding, C., & Magkos, F. (2019). The epidemiology of obesity. Metabolism, 92, 6-10.

Collison, K. S., Zaidi, M. Z., Subhani, S. N., Al-Rubeaan, K., Shoukri, M., & Al-Mohanna, F. A. (2010). Sugar-sweetened carbonated beverage consumption correlates with BMI, waist circumference, and poor dietary choices in school children. BMC public health, 10(1), 1-13.

Dinas, P. C., Lahart, I. M., Timmons, J. A., Svensson, P. A., Koutedakis, Y., Flouris, A. D., & Metsios, G. S. (2017). Effects of physical activity on the link between PGC-1a and FNDC5 in muscle, circulating Ιrisin and UCP1 of white adipocytes in humans: A systematic review. F1000Research, 6. 10.12688/f1000research.11107.1

Elizondo-Montemayor, L., Gonzalez-Gil, A. M., Tamez-Rivera, O., Toledo-Salinas, C., Peschard-Franco, M., Rodríguez-Gutiérrez, N. A., ... & Garcia-Rivas, G. (2019). Association between irisin, hs-CRP, and metabolic status in children and adolescents with type 2 diabetes mellitus. Mediators of inflammation, 2019.

Garawi, F., Devries, K., Thorogood, N., & Uauy, R. (2014). Global differences between women and men in the prevalence of obesity: is there an association with gender inequality?. European journal of clinical nutrition, 68(10), 1101-1106.

Halling, J. F., & Pilegaard, H. (2020). PGC-1α-mediated regulation of mitochondrial function and physiological implications. Applied Physiology, Nutrition, and Metabolism, 45(9), 927-936.

Ikeda, K., & Yamada, T. (2020). UCP1 dependent and independent thermogenesis in brown and beige adipocytes. Frontiers in endocrinology, 11, 498.

Jung, S., & Kim, K. (2014). Exercise-induced PGC-1α transcriptional factors in skeletal muscle. Integrative medicine research, 3(4), 155-160.

Kelly, T., Yang, W., Chen, C. S., Reynolds, K., & He, J. (2008). Global burden of obesity in 2005 and projections to 2030. International journal of obesity, 32(9), 1431-1437..

Knudsen, J. G., Murholm, M., Carey, A. L., Biensø, R. S., Basse, A. L., Allen, T. L., ... & Pilegaard, H. (2014). Role of IL-6 in exercise training-and cold-induced UCP1 expression in subcutaneous white adipose tissue. PloS one, 9(1), e84910.

Laurens, C., Bergouignan, A., & Moro, C. (2020). Exercise-released myokines in the control of energy metabolism. Frontiers in physiology, 11, 91.

Little, J. P., Safdar, A., Cermak, N., Tarnopolsky, M. A., & Gibala, M. J. (2010). Acute endurance exercise increases the nuclear abundance of PGC-1α in trained human skeletal muscle. American journal of physiology-regulatory, integrative and comparative physiology, 298(4), R912-R917.

Lobstein, T., & Jackson-Leach, R. (2006). Estimated burden of paediatric obesity and co-morbidities in Europe. Part 2. Numbers of children with indicators of obesity-related disease. International Journal of Pediatric Obesity, 1(1), 33-41.

Lupita, M. N., Merawati, D., & Sugiharto, S. (2020). Secretion Of PGC-1α By Modulating Physical Exercise To Protect Improving Obesity Prevalence. STRADA Jurnal Ilmiah Kesehatan, 9(2), 345-352.

McKie, G. L., & Wright, D. C. (2020). Biochemical adaptations in white adipose tissue following aerobic exercise: from mitochondrial biogenesis to browning. Biochemical Journal, 477(6), 1061-1081.

Norheim, F., Langleite, T. M., Hjorth, M., Holen, T., Kielland, A., Stadheim, H. K., ... & Drevon, C. A. (2014). The effects of acute and chronic exercise on PGC‐1α, irisin and browning of subcutaneous adipose tissue in humans. The FEBS journal, 281(3), 739-749.

Otero-Díaz, B., Rodríguez-Flores, M., Sánchez-Muñoz, V., Monraz-Preciado, F., Ordoñez-Ortega, S., Becerril-Elias, V., ... & Antuna-Puente, B. (2018). Exercise induces white adipose tissue browning across the weight spectrum in humans. Frontiers in physiology, 9, 1781.

Park, J. S., Holloszy, J. O., Kim, K., & Koh, J. H. (2020). Exercise training-induced PPARβ increases PGC-1α protein stability and improves insulin-induced glucose uptake in rodent muscles. Nutrients, 12(3), 652.

Petridou, A., Siopi, A., & Mougios, V. (2019). Exercise in the management of obesity. Metabolism, 92, 163-169.

Rachmi, C. N., Li, M., & Baur, L. A. (2017). Overweight and obesity in Indonesia: prevalence and risk factors—a literature review. Public health, 147, 20-29.

Skovgaard, C., Brandt, N., Pilegaard, H., & Bangsbo, J. (2016). Combined speed endurance and endurance exercise amplify the exercise‐induced PGC‐1α and PDK4 mRNA response in trained human muscle. Physiological reports, 4(14), e12864.

Sugiharto, Merawati, D., Pranoto, A., Rejeki, P. S., Lupita, M. N., Adji, B. S., Susanto, H., & Taufiq, A. (2021). Acute Interval and Continuous Moderate- Intensity Exercise Enhanced Circadian Thermogenic Activity through Browning-related Genes in Obese Adolescent Female. Malaysian Journal of Fundamental and Applied Sceinces, 17, 566-581.

Yang, S., Loro, E., Wada, S., Kim, B., Tseng, W. J., Li, K., ... & Arany, Z. (2020). Functional effects of muscle PGC-1alpha in aged animals. Skeletal Muscle, 10(1), 1-8.

Article Metrics

Abstract view : 134 times | PDF view : 13 times


  • There are currently no refbacks.



This is a website that publishes an open-access article distributed under Licensed Creative Commons License Creative Commons License the terms of the Creative Commons Attribution 4.0 International License.