The Effect Of The Methanol Extract Of Cemba's Leaves (Acacia pennata) In Lowering Blood Glucose Levels Of Male Mice (Mus musculus)

Abstract

The plants Cemba (Acacia pennata ) included is family Leguminoceae, this is plants specific in Enrekang, South Sulawesi. The research to knowing the effect of the methanol extract Cemba to decrease blood glucose levels in mices male ICR strain induced by alloxan. Cemba’s leaf are extracted using 96% methanol by maceration. This research used of randomized design (CRD) that Consist of five treatments and five repetition. The extract was dissolved using Carboxy Methyl Cellulose (CMC) 0.5% and given orally in mice that had been injected previously alloxan 120 mg / kg intraperitoneally. The extract is given different doses: 125, 250 and 500 mg / kg. Data were analyzed using Analysis of Variance (ANOVA) using SPSS Program is 2.0 and Followed by Duncan test (α 0:05), as control drugs using glibenclamide 5 mg / kg and normal control using CMC 0.5%. The results showed the methanol extract of leaves with a dose of 250 mg / kg had a most effective to decrease blood glucose levels for 14 days cemba leaf extract. Reviews these results were significantly different with normal control (105.6 mg / dl) and drug control (105.80 mg / dl), as well as groups of mice that were given the leaf extract cemba 150 and 500 mg / mm. Cemba’s leaf extract shows the effect of the decrease in blood glucose levels in mices male.
Keywords: Cemba leaf extract, family Leguminoceae, glucose level, district Enrekang